Employing single-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the framework and dynamics of chromosomes. Our analysis interests involve:

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Multicolor imaging in the bacterial nucleoid and cell division proteins with blue, orange, and near-infrared fluorescent proteins

Considering that 2000, Dekker has shifted the main target of his get the job done towards biophysics the place he experiments the Qualities of solitary biomolecules and cells utilizing the tools of nanotechnology. This transformation of subject was pushed by his fascination for the exceptional operating of Organic molecular buildings, as well as through the prolonged-term perspective that a lot of exciting discoveries is usually expected Within this area.[5] Recent traces of exploration in his biophysics team are during the parts of:[six]

2010, created a fresh way (‘wedging transfer’) to control nanostructures; initially report of DNA translocation through graphene nanopores; and realized hybrid nanopores by directed insertion of α-hemolysin into strong-condition nanopores

SMC complexes can go Actual physical roadblocks larger than their ring dimensions, indicating a nontopological mechanism for DNA loop extrusion

We form microorganisms into types that deviate from their all-natural phenotype. Particularly, I'll exhibit our capacity to form Reside E. coli bacteria into novel styles for instance rectangles, squares, triangles and circles.

2011, to start with in vitro measurements of transportation throughout an individual biomimetic nuclear pore intricate; growth of multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination

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Bulk-floor coupling identifies the mechanistic relationship between Min-protein patterns in vivo and in vitro

Screening pseudotopological and nontopological models for SMC-driven DNA loop extrusion from roadblock-traversal experiments

Character Physics thanks the nameless reviewers for their contribution to the peer evaluate of this work.

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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij fulfilled https://www.ceesdekker.net enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever design and style in 2005. (nl)